Early infarct expansion: Structural or functional?
نویسندگان
چکیده
منابع مشابه
Drug-induced expansion of infarct: morphologic and functional correlations.
It has been established that glucocorticoids and several nonsteroidal antiinflammatory drugs, when administered early after coronary occlusion, interfere with myocardial scar formation. To determine whether this action is associated with expansion of myocardial infarct during the first week of coronary occlusion and whether expansion affects ventricular function, the effects of indomethacin on ...
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Whereas the majority of influential cardiologists initially embraced the biotechnology achievement and TIM1 I superiority’ associated with tissue plasminogen activator (tPA), now the previously beleaguered streptokinase and APSAC advocates are gaining their measure of revenge after years of being intellectually suppressed by the tPA advocate^.^-^ Early infarct artery patency at whatever cost (o...
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Infarct expansion is acute regional dilatation and thinning of the infarct zone. There are several possibilities for the mechanism of this alteration in cardiac shape: thinning could be caused by 1) cell rupture, 2) a reduction in the intercellular space, or 3) stretching of myocytes or 4) slippage of groups of myocytes so that less cells are distributed across the wall. To determine the relati...
متن کاملMyocardial infarct expansion and matrix metalloproteinase inhibition.
BACKGROUND A potential mechanism for left ventricular (LV) remodeling after myocardial infarction (MI) is activation of the matrix metalloproteinases (MMPs). This study examined the effects of MMP inhibition (MMPi) on regional LV geometry and MMP levels after MI. METHODS AND RESULTS In pigs instrumented with radiopaque markers to measure regional myocardial geometry, MI was created by ligatin...
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OBJECTIVE Better prediction of tissue prognosis in acute stroke might improve treatment decisions. We hypothesized that there are metabolic ischemic disturbances measurable noninvasively by proton magnetic resonance spectroscopy ((1)H MRS) that occur earlier than any structural changes visible on diffusion-tensor imaging (DTI), which may therefore serve for territorial identification of tissue ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1985
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(85)80492-7